EVIANA

EVIANA PROJECT PAGE

GENTLE NON-INVASIVE DIAGNOSIS: CLINICAL EMBRYO FILMING

Welcome to EVIANA (Embryo Video-Monitoring Analysis) project page. This methodology is also referred to as morphokinetics (i.e., studying the dynamics of structural changes in time) to determine health and disease. These procedures also include complex data processing and analysis, such as mitometrics, cleavage rating, and various implementations of radiomics.

AIMS OF MORPHOKINETICS

To capture subtle morphological and physiological features of cells and tissues that are not comprehensible by viewing photographs or looking into a microscope. Instead, filming is performed, and accelerated or slowed-down movies or time-lapse series are analyzed in terms of morphological changes of videotaped objects over time. Transient anomalies, such as division of cells into three daughter cells instead of normal two (tripolar mitosis), cell-cell fusion of daughter cells, anomalies in timing and synchrony of biological events, and multiple other features were discovered with this approach. Some of those markers have a clinical significance (e.g., predicting embryo viability or miscarriage), and many new markers are under consideration or yet to be discovered. This is our goal and work in progress.

HOW IT WORKS

This page must not be confused with commercial services (please seek those elsewhere, including our medical and deployment partners). With us, project members are expected to dedicate their effort, data, know-how, software bits and other resources in support of the project quality and sustainability (the contribution types and extent can be individualized), and our web-based analytical functionality and other internal resources are then shared with all active members. Before we start analyzing your specimens, technical issues related to data storage, transfer and formats must be resolved. Please contact us to join our circles and submit your data for cleavage analysis, or to suggest other specimens and markers, or to develop joint research projects and grants, or for technology transfers and health care / medical / industrial / scientific implementation and deployment of our research and technologies: telemed@cyberservices.com.

LEGAL ISSUES

Please note that our non-profit organization publishes parts of our work and also performs technology transfers to commercial and non-commercial entities. We are not responsible for subsequent commercial deployment of our work by publishers, businesses and health care organizations. We are directly in charge of this project page and the related data operations, and incomes collected thru us are used for support of our mission and goals.

MAJOR ACHIEVEMENTS AND AWARDS

This project has critically contributed to a fundamental transformation of clinical embryo care and human embryo diagnosis. Parts of the project outcomes are deployed in commercial clinical applications, worldwide.

2011

Best Contribution Award, CGOS, 21th Symposium on Assisted Reproduction

2010

Best Abstract Award, CGOS, 20th Symposium on Assisted Reproduction:

Worldwide priority, first clinical analysis of in vitro human embryo filming